Drug Schedules to the Rules
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Pharmacist's Guide

Table of Contents
Drug Mechanism of Action (MOA)

Understanding the mechanism of action of a drug is the most fundamental and thorough way of understanding how it does what it does. The mechanism of action provides knowledge of the causal pathway by which a drug acts on the body.

Sno Mechanism of Action (MOA) Drugs
1 DNA Dependent RNA Polymerase Rifampcin
2 RNA Dependent DNA Polymerase Zidovudine
3 Proetin Synthesis Blocker Erythromycin, Chloramphenicol & Tetracycline
4 ACE Inhibitor Captopril
5 Ca Channel Blocker Nifedipine, Diltiazem
6 COX Inhibitor Asprin
7 GABA Facilitator Benzodiazepines
8 Antimetabolites Methotrexate
9 Loop Diuretics Frusemide
10 High Ceiling Diuretics Spironolactone
11 Alteration of bacterial DNA Choloroquine
12 Inhibition of Viral replication Amantidine, Acyclovir
13 H1 blocking agent Mepyramine, Loratadine
14 H2 Blocking agent Rantidine, Cimetidine, Famotidine, Cyprohaptidine
15 Proton Pump inhibitor Omeprazole
16 DNA Metabolism Inhibitors Quinacrine (Mepacrine)
17 Spindle Poison Vinca, Griesofulvin
18 Folic acid synthesis inhibitor DDS
19 GABA Inhibitor Sodium Valproate
20 DNA Synthesis Prevention Nalidixic Acid
21 Prostaglandin Synthesis Inhibition Oxyphenbutazone, Ibuprofen
22 Mycolic acid synthesis inhibition INH
23 Folic acid antagonist MTX, PAS, DDS & Primethamine
24 Desruption of DNA structure MNZ
25 Inhibition of cell wall synthesis Beta lactam antibiotics (penicillin)
26 Release of nor epinephrine Ephedrine
27 Ergosterol Biosnythesis Inhibitors Clotrimazole, Miconalzole, Ketoconazole
28 Ach esterase inhibitors Physostigmine, Neostigmine, Edrophonium, Metrifonate
29 Reverse Transcriptase Inhibitors Stavudine, zidovudine
30 Inhibition of HIV Protease Amepranavir
31 DNA Gyrase Inhibitor Cinoxacin
32 Inhibition of DNA Polymerase Gossypol
33 NMDA Receptor Antagonist Amantadine, Ketamine, Dextromethorphan, Memantine & Nitrous Oxide
34 DNA intercalating agent Daunorubicin, Doxorubicin, Ellipticin & Ethidium Bromide
35 Antim mitotic agent Amphethenile
36 Alkylating agent Thiotepa
37 Alpha receptor antagonist Phentolamine
38 Beta receptor antagonist Propanolol, Aplrenolol
39 Alpha receptor agonist Norepinehrine
40 Beta receptor agonist Isoproterenol & Salbutamol
41 DNA Adduct Formation Procarbazine
42 Carbonic anhydrase inhibitor Acetazolamide
43 Phosphodiestrase Inhibitor Theophylline
44 Thrombin action prevention Heparin
45 Xanthine oxidase inhibitor Allopurinol
46 Cholinergic Blockade Ipratropium
47 Adenosine Deaminase inhibitor Crisnatapase
48 Immunomodulation Imiquimod
49 Amino acid transfer interference Econazole
50 Mast Cell Stabilization Ketosifen



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